First-in-class synthetic lysin
1 in 4 women (aged 15-49) p.a. globally
60% within 6 months
Broad-spectrum antibiotics (acute) and long-term suppressive antibiotics (chronic)
PM-477 has a cleaving domain. After it binds to the cell wall, it lyses it. The cell bursts and the bacteria die.
PM-477 has a Gardnerella specific binding domain. It only binds to the cell wall of Gardnerella bacteria. It is specific.
Target pathogen: Gardnerella spp.
Indication: recurrent bacterial vaginosis
Scientific Advisory Board